A faulty Outlook profile can create an issue for this problem. To resolve the problem Outlook Data File Cannot be Accessed, try creating a new profile. The symptoms of the mistake are as follows. When you use Outlook 2010 to exchange or send/receive an email, you may encounter one of the following error messages.

1. 0x8004010F: Access to the Outlook data file is prohibited.

2. The number 0x8004010F denotes a failure of operations.